Roles and mechanisms of alternative splicing in cancer—implications for care
Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …
A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target
The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has
recently gained interest, and different DDR inhibitors have been developed. Among them …
recently gained interest, and different DDR inhibitors have been developed. Among them …
Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry
Single-cell proteomics can reveal cellular phenotypic heterogeneity and cell-specific
functional networks underlying biological processes. Here, we present a streamlined …
functional networks underlying biological processes. Here, we present a streamlined …
Targeting Wee1 kinase as a therapeutic approach in Hematological Malignancies
S Vakili-Samiani, AT Jalil, WK Abdelbasset… - DNA repair, 2021 - Elsevier
Hematologic malignancies include various diseases that develop from hematopoietic stem
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …
cells of bone marrow or lymphatic organs. Currently, conventional DNA-damage-based …
Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
A SIRT7-dependent acetylation switch regulates early B cell differentiation and lineage commitment through Pax5
A Gamez-Garcia, M Espinosa-Alcantud… - Nature …, 2024 - nature.com
B lymphopoiesis is orchestrated by lineage-specific transcription factors. In B cell
progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell …
progenitors, lineage commitment is mediated by Pax5, which is commonly mutated in B cell …
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Cancer heterogeneity at the proteome level may explain differences in therapy response
and prognosis beyond the currently established genomic and transcriptomic-based …
and prognosis beyond the currently established genomic and transcriptomic-based …
In silico investigations identified Butyl Xanalterate to competently target CK2α (CSNK2A1) for therapy of chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B-cells. In this study,
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …
RNA-binding proteins in hematopoiesis and hematological malignancy
RNA-binding proteins (RBPs) regulate fundamental processes, such as differentiation and
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …
self-renewal, by enabling the dynamic control of protein abundance or isoforms or through …
The protein landscape of chronic lymphocytic leukemia
F Meier-Abt, J Lu, E Cannizzaro… - Blood, The Journal …, 2021 - ashpublications.org
Many functional consequences of mutations on tumor phenotypes in chronic lymphocytic
leukemia (CLL) are unknown. This may be in part due to a scarcity of information on the …
leukemia (CLL) are unknown. This may be in part due to a scarcity of information on the …