Calpain-1 and calpain-2 are calcium-dependent Cys-proteases ubiquitously expressed in
mammalian tissues with a processive, rather than degradative activity. They are crucial for …

Guanine nucleotide exchange factors (GEFs) are primarily involved in signal transmission
between cell membrane receptors and intracellular mediators. Upon replacing GDP with …

Rho GTPases play a key role in the spatio-temporal coordination of cytoskeletal dynamics
during cell migration. Here, we directly investigate crosstalk between the major Rho …

Protein structure has been well established to play a key role in determining function;
however, intrinsically disordered proteins and regions (IDPs and IDRs) defy this paradigm …

RhoA and its effectors, the transcriptional coactivators myocardin-related transcription factor
(MRTF) and serum response factor (SRF), control epithelial phenotype and are …

Abstract Plakophilin 4 (PKP4) is a component of cell–cell junctions that regulates
intercellular adhesion and Rho-signaling during cytokinesis with an unknown function …

Ras homolog gene family member A (RhoA) belongs to the Rho GTPase superfamily, which
was first studied in cancers as one of the essential regulators controlling cellular function …

Target antigens are crucial for develo** chimeric antigen receptor (CAR)-T cells, but their
application to ovarian cancers is limited. This study aimed to identify potential genes as CAR …

The evolutionarily conserved apical Crumbs (CRB) complex, consisting of the core
components CRB3a (an isoform of CRB3), PALS1 and PATJ, plays a key role in epithelial …

Stress generation by the actin cytoskeleton shapes cells and tissues. Despite impressive
progress in live imaging and quantitative physical descriptions of cytoskeletal network …