Biodemography of human ageing

JW Vaupel - Nature, 2010 - nature.com
Human senescence has been delayed by a decade. This finding, documented in 1994 and
bolstered since, is a fundamental discovery about the biology of human ageing, and one …

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

DR Seals, JN Justice, TJ LaRocca - The Journal of physiology, 2016 - Wiley Online Library
Most nations of the world are undergoing rapid and dramatic population ageing, which
presents great socio‐economic challenges, as well as opportunities, for individuals, families …

[LIBRO][B] Measuring well-being: Interdisciplinary perspectives from the social sciences and the humanities

MT Lee, LD Kubzansky, TJ VanderWeele - 2021 - books.google.com
This edited volume focuses on both conceptual and practical challenges in measuring well-
being. Leveraging insights across diverse disciplines, including psychology, economics …

Differences in life expectancy due to race and educational differences are widening, and many may not catch up

SJ Olshansky, T Antonucci, L Berkman, RH Binstock… - Health …, 2012 - healthaffairs.org
It has long been known that despite well-documented improvements in longevity for most
Americans, alarming disparities persist among racial groups and between the well-educated …

Healthy aging and muscle function are positively associated with NAD+ abundance in humans

GE Janssens, L Grevendonk, RZ Perez… - Nature Aging, 2022 - nature.com
Skeletal muscle is greatly affected by aging, resulting in a loss of metabolic and physical
function. However, the underlying molecular processes and how (lack of) physical activity is …

Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet

DC Willcox, G Scapagnini, BJ Willcox - Mechanisms of ageing and …, 2014 - Elsevier
The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes),
green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods …

Substantial health and economic returns from delayed aging may warrant a new focus for medical research

DP Goldman, D Cutler, JW Rowe, PC Michaud… - Health …, 2013 - healthaffairs.org
Recent scientific advances suggest that slowing the aging process (senescence) is now a
realistic goal. Yet most medical research remains focused on combating individual diseases …

Human serum metabolic profiles are age dependent

Z Yu, G Zhai, P Singmann, Y He, T Xu, C Prehn… - Aging cell, 2012 - Wiley Online Library
Understanding the complexity of aging is of utmost importance. This can now be addressed
by the novel and powerful approach of metabolomics. However, to date, only a few …

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging

DF Dai, LF Santana, M Vermulst, DM Tomazela… - Circulation, 2009 - ahajournals.org
Background—Age is a major risk for cardiovascular diseases. Although mitochondrial
reactive oxygen species have been proposed as one of the causes of aging, their role in …

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

LW Harries, D Hernandez, W Henley, AR Wood… - Aging cell, 2011 - Wiley Online Library
Aging is a major risk factor for chronic disease in the human population, but there are little
human data on gene expression alterations that accompany the process. We examined …