Highlights•CCS distributions and shifts contain valuable information about
analytes.•Compound-dependent effects of gas, field and temperature explain calibration …

During the past two decades, density-functional (DF) theory has evolved from niche
applications for simple solid-state materials to become a workhorse method for studying a …

The diversity of stereochemical isomers present in glycans and glycoconjugates poses a
formidable challenge for comprehensive structural analysis. Typically, sophisticated mass …

Gas-phase, double resonance IR spectroscopy has proven to be an excellent approach to
obtain structural information on peptides ranging from single amino acids to large peptides …

Native mass spectrometry has emerged as an important tool for gas-phase structural
biology. However, the conformations that a biomolecular ion adopts in the gas phase can …

Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of
interest out of small quantities of heterogenous mixtures via a combination of m/z and …

Although there have been substantial improvements in glycan analysis over the past
decade, the lack of both high-resolution and high-throughput methods hampers progress in …

The separation and detection of isomers remains a challenge for many areas of mass
spectrometry. This article highlights laser photodissociation and ion mobility strategies that …

There is currently a strong interest in the use of ion mobility spectrometry-mass spectrometry
(IMS-MS) instrumentation for structural biology. In these applications, momentum transfer …

Ion mobility spectrometry–mass spectrometry methods offer the potential to correlate protein
tertiary and quaternary structures to variations in their amino acid sequences and post …