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A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Human intestinal morphogenesis establishes 3D epithelial microarchitecture and spatially
organized crypt–villus characteristics. This unique structure is necessary to maintain …
organized crypt–villus characteristics. This unique structure is necessary to maintain …
[HTML][HTML] Organoids and organs-on-chips: Insights into human gut-microbe interactions
The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …
[HTML][HTML] Journey of organ on a chip technology and its role in future healthcare scenario
Organ on a chip refers to microengineered biomimetic system which reflects structural and
functional characteristics of human tissue. It involves biomaterial technology, cell biology …
functional characteristics of human tissue. It involves biomaterial technology, cell biology …
Joint-on-chip platforms: entering a new era of in vitro models for arthritis
Arthritis affects millions of people worldwide. With only a few disease-modifying drugs
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …
Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …
[HTML][HTML] Organ-on-a-chip microengineering for bio-mimicking disease models and revolutionizing drug discovery
The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …
From animal testing to in vitro systems: advancing standardization in microphysiological systems
Limitations with cell cultures and experimental animal-based studies have had the scientific
and industrial communities searching for new approaches that can provide reliable human …
and industrial communities searching for new approaches that can provide reliable human …
Skin-on-a-chip technology: microengineering physiologically relevant in vitro skin models
The increased demand for physiologically relevant in vitro human skin models for testing
pharmaceutical drugs has led to significant advancements in skin engineering. One of the …
pharmaceutical drugs has led to significant advancements in skin engineering. One of the …
Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development: A review
Microfluidics is a revolutionary technology that has promising applications in the biomedical
field. Integrating microfluidic technology with the traditional assays unravels the innumerable …
field. Integrating microfluidic technology with the traditional assays unravels the innumerable …