Label-free biomedical optical imaging

NT Shaked, SA Boppart, LV Wang, J Popp - Nature photonics, 2023 - nature.com
Label-free optical imaging employs natural and non-destructive approaches to visualize
biomedical samples for both biological assays and clinical diagnosis. At present, this field …

High-resolution transcranial optical imaging of in vivo neural activity

AT Lefebvre, CL Rodriguez, E Bar-Kochba… - Scientific Reports, 2024 - nature.com
Rapid sub-nanometer neuronal deformations have been shown to occur as a consequence
of action potentials in vitro, allowing for optical registration of discrete axonal and synaptic …

Comparative analysis of full-field OCT and optical transmission tomography

S Alhaddad, O Thouvenin, M Boccara… - Biomedical Optics …, 2023 - opg.optica.org
This work compares two tomographic imaging technologies, time-domain full-field optical
coherence tomography (FFOCT) working in reflection and optical transmission tomography …

Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction

S Tomczewski, A Curatolo, A Foik, P Węgrzyn… - Proceedings of the …, 2025 - pnas.org
In this study, we used an inhibitor of phosphodiesterase 6 (PDE6) to examine the impact of
changes in the conformation of the PDE6 protein on the light-induced process responsible …

Single-shot off-axis full-field optical coherence tomography

EM Seromenho, A Marmin, S Facca, N Bahlouli… - Applied Physics …, 2022 - pubs.aip.org
Full field optical coherence tomography (FF-OCT) enables high-resolution in-depth imaging
within turbid media. In this work, we present a simple approach which combines FF-OCT …

Bichromatic tetraphasic full-field optical coherence microscopy

RR Iyer, M Žurauskas, Y Rao… - … of biomedical optics, 2024 - spiedigitallibrary.org
Significance Full-field optical coherence microscopy (FF-OCM) is a prevalent technique for
backscattering and phase imaging with epi-detection. Traditional methods have two …

Phase-sensitive detection of anomalous diffusion dynamics in the neuronal membrane induced by ion channel gating

H Choi, RR Iyer, CA Renteria… - Physics in Medicine & …, 2023 - iopscience.iop.org
Non-ergodicity of neuronal dynamics from rapid ion channel gating through the membrane
induces membrane displacement statistics that deviate from Brownian motion. The …

VAMPIRE microscopy enables fast and simultaneous structural, metabolic, and chemical characterization of living tissues label-free

RR Iyer, JE Sorrells, L Yang… - … Microscopy in the …, 2024 - spiedigitallibrary.org
We present a completely label-free technology that captures eight complementary contrasts
describing the metabolic, chemical, structural, and dynamic profiles of the tissue …