A variety of neurotrophic factors have been used in attempts to improve morphological and
behavioural outcomes after experimental spinal cord injury (SCI). Here we review many of …

The application of neurotrophic factors as a therapy to improve morphological and
behavioral outcomes after experimental spinal cord injury (SCI) has been the focus of many …

During vertebrate embryonic development, the spinal cord is formed by the neural
derivatives of a neuromesodermal population that is specified at early stages of …

Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …

Objectives A major impediment for recovery after mammalian spinal cord injury (SCI) is the
glial scar formed by proliferating reactive astrocytes. Finding factors that may reduce glial …

Spinal cord injury (SCI) is a disabling condition resulting in deficits of sensory and motor
functions, and has no effective treatment. Considering that protocols with stem cell …

Central nervous system neurons in adult mammals display limited regeneration after injury,
and functional recovery is poor following complete transection (> 4 mm gap) of a rat spinal …

Spinal cord injury commonly leads to permanent motor and sensory deficits due to the
limited regenerative capacity of the adult central nervous system (CNS). Nucleic acid-based …

Purpose Peripheral nerve trauma results in functional loss in the innervated organ, and
recovery without surgical intervention is rare. Many surgical techniques can be used for …

Objective We aimed to investigate whether an innovative growth factor-laden scaffold
composed of acellular sciatic nerve (ASN) and brain-derived neurotrophic factor (BDNF) …