Lawsone unleashed: A comprehensive review on chemistry, biosynthesis, and therapeutic potentials

AS Nair, M Sekar, SH Gan, V Kumarasamy… - Drug Design …, 2024 - Taylor & Francis
Lawsone, a naturally occurring organic compound also called hennotannic acid, obtained
mainly from Lawsonia inermis (Henna). It is a potential drug-like molecule with unique …

Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

P Sadhukhan, M Kundu, S Chatterjee, N Ghosh… - Materials science and …, 2019 - Elsevier
Naturally occurring bioactive compounds are gaining much importance as anti-tumor agents
in recent times due to their high therapeutic potential and less systemic toxicity. However …

Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer's disease

P Sadhukhan, S Saha, S Dutta, S Mahalanobish… - Pharmacological …, 2018 - Elsevier
Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative
disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized …

[HTML][HTML] pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy

M Kundu, P Sadhukhan, N Ghosh, S Chatterjee… - Journal of advanced …, 2019 - Elsevier
Nanoparticle-mediated targeted delivery of bioactive natural compounds has recently been
gaining much interest for breast cancer therapy. Herein, phenyl boronic acid (PBA) …

Synthesis of green carbon dots as bioimaging agent and drug delivery system for enhanced antioxidant and antibacterial efficacy

N Tejwan, M Kundu, N Ghosh, S Chatterjee… - Inorganic Chemistry …, 2022 - Elsevier
Now-a-days, synthesis of carbon dots (CDs) from renewable sources has attracted
considerable attention due to their wide spread availability, lower cost, higher aqueous …

[HTML][HTML] Microwave induced synthesis of ZnO nanorods and their efficacy as a drug carrier with profound anticancer and antibacterial properties

P Sadhukhan, M Kundu, S Rana, R Kumar, J Das… - Toxicology Reports, 2019 - Elsevier
In the present study, we report the microwave-induced synthesis of fluorescent zinc oxide
nanorods (ZnO) and their usage as a cargo material to carry hydrophobic drug, quercetin …

Melatonin attenuates arsenic induced nephropathy via the regulation of oxidative stress and inflammatory signaling cascades in mice

S Dutta, S Saha, S Mahalanobish, P Sadhukhan… - Food and Chemical …, 2018 - Elsevier
Arsenic is a potent inducer of several acute and chronic nephrotoxic disorders. It promotes
deleterious phenomenon like oxidative stress, inflammation, cell death and altered glucose …

In vivo therapeutic evaluation of a novel bis-lawsone derivative against tumor following delivery using mesoporous silica nanoparticle based redox-responsive drug …

M Kundu, P Sadhukhan, N Ghosh, S Ghosh… - Materials Science and …, 2021 - Elsevier
Herein, we have evaluated the in vivo therapeutic efficacy and systemic toxicity profile of a
synthetic anticancer compound [3, 3′-((4-(trifluoromethyl) phenyl) methylene) bis (2 …

Mangiferin ameliorates cisplatin induced acute kidney injury by upregulating Nrf-2 via the activation of PI3K and exhibits synergistic anticancer activity with cisplatin

P Sadhukhan, S Saha, S Dutta, PC Sil - Frontiers in Pharmacology, 2018 - frontiersin.org
Occurrence of oxidative stress is the principal cause of acute kidney injury induced by
cisplatin. Mangiferin, a naturally occurring antioxidant molecule, is found to ameliorate …

Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress …

GI Abd El-Rahman, A Behairy, NM Elseddawy… - Antioxidants, 2020 - mdpi.com
Background: In this era, worldwide interest has been directed towards using natural
antioxidants to guard against drug side effects. Saussurea lappa is a famous medicinal plant …