RNA interference (RNAi) is considered a highly specific approach for gene silencing and
holds tremendous potential for treatment of various pathologic conditions such as …

Cardiovascular disease (CVD) has overtaken infectious illnesses as the leading cause of
mortality and disability worldwide. The pathology that underpins CVD is atherosclerosis …

Polymeric micelles are a prevalent topic of research for the past decade, especially
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …

P-glycoprotein (Pgp) mediated multi-drug resistance (MDR) is a major cause of failure in
chemotherapy. In this study, small interfering RNA (siRNA) for Pgp down-regulation was …

Inhibiting specific gene expression by short interfering RNA (siRNA) offers a new therapeutic
strategy to tackle many diseases, including cancer, metabolic disorders, and viral infections …

Survivin, also known as baculoviral inhibitor of apoptosis repeat‑containing 5, is a novel
member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors …

Small interfering RNA (siRNA) has gained attention as a potential therapeutic reagent due to
its ability to inhibit specific genes in many genetic diseases. For many years, studies of …

Structural modifications of the siRNA backbone improved its physiochemical properties for
incorporating in gene carriers without loss of gene-silencing efficacy. These modifications …

Systemic delivery of siRNA to target tissues is difficult to achieve owing to its limited cellular
uptake and poor serum stability. Herein, polymeric nanoparticles were developed for …

For therapeutic applications of siRNA, there are technical challenges with respect to
targeted and systemic delivery. We here report a new siRNA carrier, RNAtr NPs, in a way …