Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease

N Kordana, A Johnson, K Quinn, JJ Obar… - Microbiology and …, 2025 - journals.asm.org
Advances in modern medical therapies for many previously intractable human diseases
have improved patient outcomes. However, successful disease treatment outcomes are …

Variability in competitive fitness among environmental and clinical azole-resistant Aspergillus fumigatus isolates

S Chen, G Zhu, H Lin, J Guo, S Deng, W Wu… - MBio, 2024 - journals.asm.org
Azoles are the primary antifungal drugs used to treat infections caused by Aspergillus
fumigatus. However, the emergence of azole resistance in A. fumigatus has become a …

Azole resistance mechanisms and population structure of the human pathogen Aspergillus fumigatus on retail plant products

C Wang, N Miller, D Vines, PM Severns… - Applied and …, 2024 - journals.asm.org
Aspergillus fumigatus is a ubiquitous saprotroph and human-pathogenic fungus that is life-
threatening to the immunocompromised. Triazole-resistant A. fumigatus was found in …

Pan-azole- and multi-fungicide-resistant Aspergillus fumigatus is widespread in the United States

BN Celia-Sanchez, B Mangum… - Applied and …, 2024 - journals.asm.org
Aspergillus fumigatus is an important global fungal pathogen of humans. Azole drugs are
among the most effective treatments for A. fumigatus infection. Azoles are also widely used …

Wake-up call: rapid increase in human fungal diseases under climate change

L Konkel Neabore - 2024 - ehp.niehs.nih.gov
Wake-up Call: Rapid Increase in Human Fungal Diseases under Climate Change |
Environmental Health Perspectives | Vol. 132, No. 4 Skip to main content EHP Publishing …

Examination of genome-wide ortholog variation in clinical and environmental isolates of the fungal pathogen Aspergillus fumigatus

MAC Horta, JL Steenwyk, ME Mead, LHB Dos Santos… - Mbio, 2022 - journals.asm.org
Aspergillus fumigatus is both an environmental saprobe and an opportunistic human fungal
pathogen. Knowledge of genomic variation across A. fumigatus isolates is essential for …

[HTML][HTML] A single fungal strain was the unexpected cause of a mass aspergillosis outbreak in the world's largest and only flightless parrot

DJ Winter, BS Weir, T Glare, J Rhodes, J Perrott… - Iscience, 2022 - cell.com
Kākāpō are a critically endangered species of parrots restricted to a few islands off the coast
of New Zealand. Kākāpō are very closely monitored, especially during nesting seasons. In …

Induction of Aspergillus fumigatus zinc cluster transcription factor OdrA/Mdu2 provides combined cellular responses for oxidative stress protection and multiple …

C Sasse, E Bastakis, F Bakti, AM Höfer, I Zangl… - Mbio, 2023 - journals.asm.org
ABSTRACT Z inc c luster transcription f actors (Zcfs) encoding zcf genes are exclusive for
fungi and required for multiple cellular processes including metabolism and development …

Metagenome meta-analysis reveals an increase in the abundance of some multidrug efflux pumps and mobile genetic elements in chemically polluted environments

J Subirats, H Sharpe, V Tai, M Fruci… - Applied and …, 2023 - journals.asm.org
Many human activities contaminate terrestrial and aquatic environments with numerous
chemical pollutants that not only directly alter the environment but also affect microbial …

Aneuploidy Formation in the filamentous fungus Aspergillus flavus in response to azole stress

O Barda, S Sadhasivam, D Gong… - Microbiology …, 2023 - journals.asm.org
Aspergillus flavus is a mycotoxigenic fungus that contaminates many important agricultural
crops with aflatoxin B1, the most toxic and carcinogenic natural compound. This fungus is …