The mammalian nervous system is comprised of a seemingly infinitely complex network of
specialized synaptic connections that coordinate the flow of information through it. The field …

Both observational and perturbational technologies are essential for advancing the
understanding of brain function and dysfunction. But while observational techniques have …

Gene therapy aims to revert diseased phenotypes by the use of both viral and nonviral gene
delivery systems. Substantial progress has been made in making gene transfer vehicles …

Adeno-associated viral vectors are widely used as vehicles for gene transfer to the nervous
system. The promoter and viral vector serotype are two key factors that determine the …

The optogenetic approach to gain control over neuronal excitability both in vitro and in vivo
has emerged as a fascinating scientific tool to explore neuronal networks, but it also opens …

Lentiviruses have been extensively used as gene delivery vectors since the mid-1990s.
Usually derived from the human immunodeficiency virus genome, they mediate efficient …

Gene transfer is an increasingly utilized approach for research and clinical applications
involving the central nervous system (CNS). Vectors for gene transfer can be as simple as …

The management of disorders of the nervous system remains a medical challenge. The key
goals are to understand disease mechanisms, to validate therapeutic targets, and to develop …

Although many of the physiological effects of corticosteroid stress hormones on neuronal
function are well recognised, the underlying genomic mechanisms are only starting to be …

Dravet syndrome is a genetic encephalopathy characterized by severe epilepsy combined
with motor, cognitive, and behavioral abnormalities. Current antiepileptic drugs achieve only …