Therapeutic interventions in patients with prolonged disorders of consciousness

A Thibaut, N Schiff, J Giacino, S Laureys… - The Lancet …, 2019 - thelancet.com
The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

Changing brain networks through non-invasive neuromodulation

WT To, D De Ridder, J Hart Jr… - Frontiers in human …, 2018 - frontiersin.org
Background/Objective: Non-invasive neuromodulation techniques, such as repetitive
Transcranial Magnetic Stimulation (rTMS) and transcranial Direct Current Stimulation …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Differential role of prefrontal and parietal cortices in controlling level of consciousness

D Pal, JG Dean, T Liu, D Li, CJ Watson, AG Hudetz… - Current Biology, 2018 - cell.com
Consciousness is determined both by level (eg, being awake versus being anesthetized)
and content (ie, the qualitative aspects of experience). Subcortical areas are known to play a …

Sleep-like cortical OFF-periods disrupt causality and complexity in the brain of unresponsive wakefulness syndrome patients

M Rosanova, M Fecchio, S Casarotto, S Sarasso… - Nature …, 2018 - nature.com
Unresponsive wakefulness syndrome (UWS) patients may retain intact portions of the
thalamocortical system that are spontaneously active and reactive to sensory stimuli but fail …

Ultrasonic deep brain neuromodulation in acute disorders of consciousness: a proof-of-concept

JA Cain, NM Spivak, JP Coetzee, JS Crone… - Brain sciences, 2022 - mdpi.com
The promotion of recovery in patients who have entered a disorder of consciousness (DOC;
eg, coma or vegetative states) following severe brain injury remains an enduring medical …

Randomized controlled trial of home-based 4-week tDCS in chronic minimally conscious state

G Martens, N Lejeune, AT O'Brien, F Fregni, C Martial… - Brain stimulation, 2018 - Elsevier
Background Patients with chronic disorders of consciousness face a significant lack of
treatment options. Objective We aimed at investigating the feasibility and the behavioral …

Proceedings of the first curing coma campaign NIH symposium: challenging the future of research for coma and disorders of consciousness

J Claassen, Y Akbari, S Alexander, MK Bader, K Bell… - Neurocritical care, 2021 - Springer
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden
for patients, families, and society worldwide. As part of the Curing Coma Campaign, the …

Repetitive transcranial magnetic stimulation improves consciousness in some patients with disorders of consciousness

J Fan, Y Zhong, H Wang, N Aierken… - Clinical …, 2022 - journals.sagepub.com
Objective To investigate the therapeutic efficacy of repetitive transcranial magnetic
stimulation (rTMS) in patients with disorders of consciousness. Design and Setting We …

Sham‐controlled randomized multicentre trial of transcranial direct current stimulation for prolonged disorders of consciousness

A Thibaut, F Fregni, A Estraneo… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Transcranial direct current stimulation (tDCS) has been shown to
improve signs of consciousness in a subset of patients with disorders of consciousness …