Osteoarthritis (OA) is the most prevalent degenerative joint disease, marked by cartilage
degeneration, synovitis, and subchondral bone changes. The absence of effective drugs …

In degenerative joint disease like osteoarthritis (OA), bioactive compounds like resveratrol,
epigallocatechin gallate, curcumin, and other polyphenols often target various signalling …

Osteoarthritis is a common degenerative disease characterized by continuous detachment
of lubrication factors from damaged cartilage matrix. This study proposes a paradigm that …

Presently, the clinical treatment of intervertebral disc degeneration (IVDD) remains
challenging, but the strategy of simultaneously overcoming the overactive inflammation and …

Bone tissue engineering based on seed cells, biomimetic scaffolds and growth factors
emerges as a novel therapeutic option for bone defect. The survival, retention, and function …

Commonly, articular osteochondral tissue exists significant differences in physiological
architecture, mechanical function, and biological microenvironment. However, the …

Organ injuries, such as acute kidney injury, ischemic stroke, and spinal cord injury, often
result in complications that can be life-threatening or even fatal. Recently, many …

The excessive reactive oxygen species (ROS) accumulation and overactivated
osteoclastogenesis in subchondral bone has proved to be a major cause of osteoarthritis …

Neuropathic pain (NP) represents a considerable clinical challenge, profoundly impacting
patients' quality of life. Presently, pharmacotherapy serves as a primary approach for NP …

Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma
membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic …