Perivascular spaces in the brain: anatomy, physiology and pathology

JM Wardlaw, H Benveniste, M Nedergaard… - Nature Reviews …, 2020 - nature.com
Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

Inflammation and cerebral small vessel disease: a systematic review

A Low, E Mak, JB Rowe, HS Markus, JT O'Brien - Ageing research reviews, 2019 - Elsevier
Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

[HTML][HTML] Emerging concepts in vascular dementia: a review

SC Bir, MW Khan, V Javalkar, EG Toledo… - Journal of Stroke and …, 2021 - Elsevier
Abstract Objective Vascular dementia (VaD) is the second most common cause of dementia
and a major health concern worldwide. A comprehensive review on VaD is warranted for …

Association of dilated perivascular spaces with cognitive decline and incident dementia

M Paradise, JD Crawford, BCP Lam, W Wen… - Neurology, 2021 - AAN Enterprises
Objective To determine whether severe perivascular space (PVS) dilation is associated with
longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we …

[HTML][HTML] Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Q Yang, X Wei, B Deng, Z Chang, D **, Y Huang… - Neurobiology of …, 2022 - Elsevier
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …

Association of enlarged perivascular spaces and measures of small vessel and Alzheimer disease

EC Gertje, D van Westen, C Panizo… - Neurology, 2021 - AAN Enterprises
Objective To investigate the relationship between enlarged perivascular spaces (EPVS) and
measures of Alzheimer disease (AD), small vessel disease (SVD), cognition, vascular risk …

[HTML][HTML] Imaging perivascular space structure and function using brain MRI

G Barisano, KM Lynch, F Sibilia, H Lan, NC Shih… - Neuroimage, 2022 - Elsevier
In this article, we provide an overview of current neuroimaging methods for studying
perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing …

Physiology and clinical relevance of enlarged perivascular spaces in the aging brain

CW Bown, RO Carare, MS Schrag, AL Jefferson - Neurology, 2022 - AAN Enterprises
Perivascular spaces (PVS) are fluid-filled compartments that are part of the cerebral blood
vessel wall and represent the conduit for fluid transport in and out of the brain. PVS are …

The glymphatic system's role in traumatic brain injury-related neurodegeneration

ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …

Volumetric distribution of perivascular space in relation to mild cognitive impairment

F Sepehrband, G Barisano, N Sheikh-Bahaei… - Neurobiology of …, 2021 - Elsevier
Vascular contributions to early cognitive decline are increasingly recognized, prompting
further investigation into the nature of related changes in perivascular spaces (PVS). Using …