Autophagy in liver diseases: a review
The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …
synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid …
Liver regeneration and inflammation: from fundamental science to clinical applications
Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …
Cell death in liver diseases: a review
Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
[HTML][HTML] Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
M Yan, Y Huo, S Yin, H Hu - Redox biology, 2018 - Elsevier
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
many developed countries. Mitochondrial oxidative stress is considered to be the …
many developed countries. Mitochondrial oxidative stress is considered to be the …
Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury
Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …
western countries, and, because of translational relevance of animal models, APAP is …
Autophagy in liver diseases: time for translation?
M Allaire, PE Rautou, P Codogno, S Lotersztajn - Journal of Hepatology, 2019 - Elsevier
Autophagy is a self-eating catabolic pathway that contributes to liver homeostasis through its
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …
role in energy balance and in the quality control of the cytoplasm, by removing misfolded …
[PDF][PDF] Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) arises from a variable interplay between environmental
factors and genetic determinants that cannot be completely replicated in animals …
factors and genetic determinants that cannot be completely replicated in animals …
[HTML][HTML] Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy
Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …
Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure
Liver injury and acute liver failure caused by acetaminophen (APAP, N-acetyl-p-
aminophenol, paracetamol) overdose is a significant clinical problem in most western …
aminophenol, paracetamol) overdose is a significant clinical problem in most western …
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose
Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …
acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 …