[HTML][HTML] Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project
The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …
and the nucleus in space and time. We summarize progress by the consortium and highlight …
MYC function and regulation in physiological perspective
MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …
that regulates almost every physiological process in a cell including cell cycle, proliferation …
Phase separation of YAP-MAML2 differentially regulates the transcriptome
Phase separation (PS) drives the formation of biomolecular condensates that are emerging
biological structures involved in diverse cellular processes. Recent studies have unveiled …
biological structures involved in diverse cellular processes. Recent studies have unveiled …
Phase separation underlies signaling activation of oncogenic NTRK fusions
Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II
R Vidal, E Leen, S Herold, M Müller, D Fleischhauer… - Elife, 2024 - elifesciences.org
MYC family oncoproteins regulate the expression of a large number of genes and broadly
stimulate elongation by RNA polymerase II (RNAPII). While the factors that control the …
stimulate elongation by RNA polymerase II (RNAPII). While the factors that control the …
Dysregulation of transcriptional condensates in human disease: mechanisms, biological functions, and open questions
Highlights•Transcriptional components can form dense assemblies termed condensates.•
Transcriptional condensates arise from interactions among proteins, RNA, or …
Transcriptional condensates arise from interactions among proteins, RNA, or …