It is now well-established that early life adversity (ELA) predisposes individuals to develop
several neuropsychiatric conditions, including anxiety disorders, and major depressive …

Stress-related psychiatric disorders including depression involve complex cellular and
molecular changes in the brain, and GABAergic signaling dysfunction is increasingly …

Sex differences in motivation for food rewards, gambling, and drugs of abuse are modulated
by multiple factors, including sensory stimuli, gonadal hormones, and cognitive bias. Cues …

Compulsive alcohol drinking is a key symptom of alcohol use disorder (AUD) that is
particularly resistant to treatment. An understanding of the biological factors that underly …

Stress is a major risk factor for neurodevelopmental and neuropsychiatric disorders, with the
capacity to impact susceptibility to disease as well as long-term neurobiological and …

Introduction: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition.
Maternal separation (MS) stress is an early-life stress factor associated with behaviors …

Both early life aversive experiences and intrinsic alterations in early postnatal
neurodevelopment are considered predisposing factors for psychiatric disorders, such as …

Diffuse and structured extracellular matrix (ECM) comprise∼ 20% of the brain's volume and
play important roles in development and adult plasticity. Perineuronal nets (PNNs) …

Rationale Unconditioned tasks in rodents have been the mainstay of behavioural
assessment for decades, but their validity and sensitivity to detect the behavioural …

Exposure to early life stress (ELS) has been linked to at least double the risk of
psychopathology as well as higher morbidity and earlier mortality across the lifespan. For …