Therapeutic effects of coumarins with different substitution patterns
The use of derivatives of natural and synthetic origin has gained attention because of their
therapeutic effects against human diseases. Coumarins are one of the most common …
therapeutic effects against human diseases. Coumarins are one of the most common …
Trending topics on coumarin and its derivatives in 2020
Coumarins are naturally occurring molecules with a versatile range of activities. Their
structural and physicochemical characteristics make them a privileged scaffold in medicinal …
structural and physicochemical characteristics make them a privileged scaffold in medicinal …
Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials
Xanthine oxidase, a molybdo-flavoenzyme, and an isoform of xanthine dehydrogenase both
exist as xanthine oxidoreductase and are responsible for purine catabolism. Xanthine …
exist as xanthine oxidoreductase and are responsible for purine catabolism. Xanthine …
Inflammatory Response and Oxidative Stress as Mechanism of Reducing Hyperuricemia of Gardenia jasminoides‐Poria cocos with Network Pharmacology
L Liu, S Jiang, X Liu, Q Tang, Y Chen… - Oxidative medicine …, 2021 - Wiley Online Library
Hyperuricemia (HUA) is a metabolic disease, closely related to oxidative stress and
inflammatory responses, caused by reduced excretion or increased production of uric acid …
inflammatory responses, caused by reduced excretion or increased production of uric acid …
Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1, 2, 3-triazole-4, 5-dicarboxylate and (N-benzyl-1H …
This study focused on synthesis various dimethyl N-benzyl-1H-1, 2, 3-triazole-4, 5-
dicarboxylate and (N-benzyl-1H-1, 2, 3-triazole-4, 5-diyl) dimethanol derivatives under the …
dicarboxylate and (N-benzyl-1H-1, 2, 3-triazole-4, 5-diyl) dimethanol derivatives under the …
The inhibitory activity of natural products to xanthine oxidase
S Zhou, G Huang - Chemistry & Biodiversity, 2023 - Wiley Online Library
The natural products have a new chemical structure and biological active diversity, so they
are favored by scientific researchers. Gout is a high incidence and high‐risk disease, and …
are favored by scientific researchers. Gout is a high incidence and high‐risk disease, and …
2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases
A Fuentes-Aguilar, P Merino-Montiel… - Journal of Enzyme …, 2022 - Taylor & Francis
We have carried out the design, synthesis, and evaluation of a small library of 2-
aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and …
aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and …
Investigation of pyrimidine analogues as xanthine oxidase inhibitors to treat of hyperuricemia and gout through combined QSAR techniques, molecular docking and …
Xanthine Oxidase (XO), that catalyzes the oxidation of purine bases to uric acid with the
generation of reactive oxygen species, is a key enzyme in the pathogenesis of …
generation of reactive oxygen species, is a key enzyme in the pathogenesis of …
Synthetic heterocyclic derivatives as promising xanthine oxidase inhibitors: An overview
Inhibition of xanthine oxidase (XO) is an effective and most prominent therapeutic approach
for the management of gout. Discovery of its association in the pathophysiology of diabetes …
for the management of gout. Discovery of its association in the pathophysiology of diabetes …
[HTML][HTML] Identification of new benzofuran derivatives as STING agonists with broad-spectrum antiviral activity
A Paulis, A Onali, PO Vidalain, V Lotteau, C Jaquemin… - Virus Research, 2024 - Elsevier
Abstract The Stimulator of Interferon Genes (STING) is involved in cytosolic DNA sensing
and type I Interferons (IFN-I) induction. Aiming to identify new STING agonists with antiviral …
and type I Interferons (IFN-I) induction. Aiming to identify new STING agonists with antiviral …