Abstract Background Phosphoenolpyruvate Carboxykinase (PCK) has been almost
exclusively recognized as a critical enzyme in gluconeogenesis, especially in liver and …

Acetylation represents one of the major post-translational protein modifications, which
introduces an acetyl functional group into amino acids such as the lysine residue to yield an …

Low-affinity protein–ligand interactions are important for many biological processes,
including cell communication, signal transduction, and immune responses. Structural …

The last few decades have witnessed an advancement in our understanding of multiple
cancer cell pathways related to metabolic reprogramming. One of the most important cancer …

Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational
modifications that regulate protein function. In mitochondria, lysine acylation is …

Although it was traditionally believed that gluconeogenesis enzymes were absent from
cancers that did not originate in gluconeogenic organs, numerous investigations have …

Saturation transfer difference NMR spectroscopy has revolutionized the study of weak
receptor-ligand interactions. Its versatility and popularity are demonstrated by a myriad of …

Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme catalysing conversion of
oxaloacetate into phosphoenolpyruvate. There are two PEPCK isoforms, PEPCK-C and …

Les organismes aquatiques sont capables de répondre de manière adaptative aux effets
toxiques des contaminants chimiques présents dans l'eau. L'étude qualitative de ces …

Histone is an important component of chromatin, and its content significantly affects
chromatin high-level structure formation, gene expression, DNA replication, and other …