Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

In human populations, women consistently outlive men, which suggests profound biological
foundations for sex differences in survival. Quantifying whether such sex differences are also …

Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

Mitochondria are organelles that produce cellular energy in the form of ATP through
oxidative phosphorylation, and this primary function is conserved among many taxa …

Mitochondria perform an array of functions, many of which involve interactions with gene
products encoded by the nucleus. These mitochondrial functions, particularly those involving …

The maternal inheritance of mitochondrial genomes entails a sex-specific selective sieve,
whereby mutations in mitochondrial DNA can only respond to selection acting on females. In …

Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …

Mitochondrial genes play an essential role in energy metabolism. Variation in the
mitochondrial DNA (mtDNA) sequence often exists within species, and this variation can …

In many animal species, including humans, males have shorter lifespan and show faster
survival aging than females. This differential increase in mortality between sexes could …