Chemogenetic methods enabling the rapid translocation of specific proteins to the plasma
membrane (PM) in a single protein-single ligand manner are useful tools in cell biology. We …

Small-molecule fluorescent probes enabling visualization of the Golgi apparatus in living
cells are essential tools for studying Golgi-associated biological processes and diseases. So …

Abstract Ferrous ion (Fe 2+) is a crucial metal ion in the body and participates in the
diseases related to oxidation and reduction. Golgi apparatus is the main subcellular …

Labeled ammonium cations with pKa∼ 7.4 accumulate in acidic organelles because they
can be neutralized transiently to cross the membrane at cytosolic pH 7.2 but not at their …

Connecting two small molecules, such as ligands, fluorophores, or lipids, together via a
linker with amide bonds is a widely used strategy to generate synthetic bifunctional …

Cells sense extracellular stimuli through membrane receptors and process information
through an intracellular signaling network. Protein translocation triggers intracellular …

Manipulating subcellular protein localization using light is a powerful approach for
controlling signaling processes with high spatiotemporal precision. The most widely used …

Conjugating small-molecule ligands to synthetic motifs that can localize to specific
organelles or membranes in living cells is a practical approach to develop compounds as …