Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

The emergence of the variant of concern Omicron (B. 1.1. 529) of the severe acute
respiratory syndrome coronavirus 2 has aggravated the Covid-19 pandemic due to its very …

Electrostatic intermolecular interactions are important in many aspects of biology. We have
studied the main electrostatic features involved in the interaction of the receptor-binding …

The rise of SARS-CoV-2 variants, with changes that could be related to an increased virus
pathogenicity, have received the interest of the scientific and medical community. In this …

Background: In the last few years, in silico tools, including drug repurposing coupled with
structure-based virtual screening, have been extensively employed to look for anti-COVID …

Protein mutations occur frequently in biological systems, which may impact, for example, the
binding of drugs to their targets through impairing the critical H-bonds, changing the …

Cross-talk between Rho-and Arf-family guanosine triphosphatases (GTPases) plays an
important role in linking the actin cytoskeleton to membrane protrusions, organelle …

Biolayer interferometry (BLI) is a well-established laboratory technique for studying
biomolecular interactions important for applications such as drug development. Currently …

The severe acute respiratory syndrome virus-2 (SARS CoV-2) infection has resulted in the
current global pandemic. The binding of SARS CoV-2 spike protein receptor-binding domain …

The contagiousness of SARS-CoV-2 β-coronavirus is determined by the virus–receptor
electrostatic association of its positively charged spike (S) protein with the negatively …