Combined chemotherapy is a treatment method based on the simultaneous use of two or
more therapeutic agents; it is frequently necessary to produce a more effective treatment for …

Anxiety disorders are the most common mental diseases. Anxiety and the associated
physical symptoms may disturb social and occupational life and increase the risk of somatic …

Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Phytomelatonin is the multifunctional molecule that governs a range of developmental
processes in plants subjected to a plethora of environmental cues. It acts as an antioxidant …

Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually.
Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy …

Purpose Bone diseases account for an enormous cost burden on health systems. Bone
disorders are considered as age-dependent diseases. The aging of world population has …

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient
oxidative phosphorylation (OXPHOS) and elevated electron leakage from the electron …

Ferroptosis is a type of regulated cell death that is dependent on iron and reactive oxygen
species (ROS). Melatonin (N-acetyl-5-methoxytryptamine) reduces hypoxic–ischemic brain …