Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
COVID-19 and human reproduction: A pandemic that packs a serious punch
The COVID-19 pandemic has led to a worldwide health emergency that has impacted 188
countries at last count. The rapid community transmission and relatively high mortality rates …
countries at last count. The rapid community transmission and relatively high mortality rates …
Efficacious preclinical repurposing of the nucleoside analogue didanosine against COVID-19 polymerase and exonuclease
AM Rabie - ACS omega, 2022 - ACS Publications
Analogues and derivatives of natural nucleosides/nucleotides are considered among the
most successful bioactive species of drug-like compounds in modern medicinal chemistry …
most successful bioactive species of drug-like compounds in modern medicinal chemistry …
The COVID-19 drug and gene set library
In a short period, many research publications that report sets of experimentally validated
drugs as potential COVID-19 therapies have emerged. To organize this accumulating …
drugs as potential COVID-19 therapies have emerged. To organize this accumulating …
ASGARD is a single-cell guided pipeline to aid repurposing of drugs
Single-cell RNA sequencing technology has enabled in-depth analysis of intercellular
heterogeneity in various diseases. However, its full potential for precision medicine has yet …
heterogeneity in various diseases. However, its full potential for precision medicine has yet …
Advances in the computational landscape for repurposed drugs against COVID-19
I Aronskyy, Y Masoudi-Sobhanzadeh, A Cappuccio… - Drug Discovery …, 2021 - Elsevier
The COVID-19 pandemic has caused millions of deaths and massive societal distress
worldwide. Therapeutic solutions are urgently needed, but de novo drug development …
worldwide. Therapeutic solutions are urgently needed, but de novo drug development …
[HTML][HTML] Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase
T Xu, L Zhang - Computational and Structural Biotechnology Journal, 2023 - Elsevier
Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …
coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main …
How do we share data in COVID-19 research? A systematic review of COVID-19 datasets in PubMed Central Articles
Objective This study aims at reviewing novel coronavirus disease (COVID-19) datasets
extracted from PubMed Central articles, thus providing quantitative analysis to answer …
extracted from PubMed Central articles, thus providing quantitative analysis to answer …
Bisindolylmaleimide IX: A novel anti-SARS-CoV2 agent targeting viral main protease 3CLpro demonstrated by virtual screening pipeline and in-vitro validation assays
Abstract SARS-CoV-2, the virus that causes COVID-19 consists of several enzymes with
essential functions within its proteome. Here, we focused on repurposing approved and …
essential functions within its proteome. Here, we focused on repurposing approved and …
A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase
The outbreaks of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in 2019,
have highlighted the concerns about the lack of potential vaccines or antivirals approved for …
have highlighted the concerns about the lack of potential vaccines or antivirals approved for …