The present review is concerned with continuum and other implicit models of solvation
effects. We will concentrate on the elements required to make such models successful and …

The partitioning of membrane-active oligopeptides into membrane interfaces promotes the
formation of secondary structure. A quantitative description of the coupling of structure …

▪ Abstract Stably folded membrane proteins reside in a free energy minimum determined by
the interactions of the peptide chains with each other, the lipid bilayer hydrocarbon core, the …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

▪ Abstract We review the physical properties of phosphatidylinositol 4, 5-bisphosphate (PIP2)
that determine both its specific interactions with protein domains of known structure and its …

The clearest function of membrane lipids is to form amphipathic bilayers that surround cells
and organelles and block leakage of hydrophilic compounds while housing membrane …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2), which comprises only about 1% of
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …

Parkinson's disease is characterized by the presence of intracellular aggregates composed
primarily of the neuronal protein α-synuclein (αS). Interactions between αS and various …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

The β-amyloid peptide βAP (1− 40), a 40-amino acid residues peptide, is one of the major
components of Alzheimer's amyloid deposits. βAP (1− 40) exhibits only a limited solubility in …