Optical microscopy has been a fundamental tool of biological discovery for more than three
centuries, but its in vivo tissue imaging ability has been restricted by light scattering to …

Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical
imaging techniques for observations through biological tissue, allows 3-D quantitative …

There is a wealth of new fluorescent reporter technologies for tagging of many cellular and
subcellular processes in vivo. This imposed contrast is now captured with an increasing …

The development of hybrid optical tomography methods to improve imaging performance
has been suggested over a decade ago and has been experimentally demonstrated in …

Bioluminescence tomography (BLT) is used to localize and quantify bioluminescent sources
in a small living animal. By advancing bioluminescent imaging to a tomographic framework …

Fusion imaging of radionuclide-based molecular (PET) and structural data [x-ray computed
tomography (CT)] has been firmly established. Here we show that optical measurements …

We present the first prospective test of Raman spectroscopy in diagnosing normal, benign,
and malignant human breast tissues. Prospective testing of spectral diagnostic algorithms …

Purpose To explore the optical and physiologic properties of normal and lesion-bearing
breasts by using a combined optical and digital breast tomosynthesis (DBT) imaging system …

Using diffuse reflectance spectroscopy and intrinsic fluorescence spectroscopy, we have
developed an algorithm that successfully classifies normal breast tissue, fibrocystic change …

Many different types of radiation have been exploited to provide images of the structure and
function of tissues inside a living subject. Each imaging modality is characterized by differing …