Wet fluidized bed granulation and coating processes have been widely used in the
pharmaceutical and food industries. The complex gas–solid flow coupled with heat and …

During the coating process of medicines, premature drying of the spray droplets may cause
losses, as the droplets do not stick to the product. This work addresses two mechanisms that …

This work presents a novel time-scale extrapolation method to predict the amount and
location of the coating material on tablets based on short discrete element method (DEM) …

Atomization-based techniques are widely used in pharmaceutical industry for production of
fine drug particles due to their versatility and adaptability. Key performance measure of such …

Detailed knowledge about the gas-solid heat and mass transfer is essential for the design
and optimization of the fluidized bed coating process. Coupled computational fluid dynamics …

Tablets are usually spray-coated in the pharmaceutical industry, and coating uniformity is
important for the coating process. In this study, discrete element method-discrete droplet …

Abstract The Discrete Element Method (DEM) is commonly used for modeling the flow of
particulate materials. Unfortunately, such detailed simulations are computationally very …

Although mechanistic numerical simulations can offer great insights into a process, they are
limited with respect to resolved process time. While statistical models provide long-term …

The current study aims to apply an innovative mathematical model based on the discrete
element method to numerically simulate the electrostatic dry powder coating process and to …

Calibration of contact parameters for the DEM approach remains one of the critical obstacles
for an accurate description of powder flows. Ideally, such a calibration approach relies on …