Is there more to GABA than synaptic inhibition?
DF Owens, AR Kriegstein - Nature Reviews Neuroscience, 2002 - nature.com
In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development …
neurotransmitter. But it can also act as a trophic factor during nervous system development …
GABA and GABA receptors in the central nervous system and other organs
M Watanabe, K Maemura, K Kanbara… - International review of …, 2002 - Elsevier
γ-Aminobutyrate (GABA) is a major inhibitory neurotransmitter in the adult mammalian brain.
GABA is also considered to be a multifunctional molecule that has different situational …
GABA is also considered to be a multifunctional molecule that has different situational …
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the α5 subunit of the GABAAReceptor
N Collinson, FM Kuenzi, W Jarolimek… - Journal of …, 2002 - Soc Neuroscience
The α5 subunit of the GABAA receptor is localized mainly to the hippocampus of the
mammalian brain. The significance of this rather distinct localization and the function of α5 …
mammalian brain. The significance of this rather distinct localization and the function of α5 …
Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase
H Asada, Y Kawamura, K Maruyama… - Proceedings of the …, 1997 - National Acad Sciences
In addition to its role as an inhibitory neurotransmitter, γ-aminobutyric acid (GABA) is
presumed to be involved in the development and plasticity of the nervous system. GABA is …
presumed to be involved in the development and plasticity of the nervous system. GABA is …
Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
M Levin - Molecular biology of the cell, 2014 - Am Soc Cell Biol
In addition to biochemical gradients and transcriptional networks, cell behavior is regulated
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …
by endogenous bioelectrical cues originating in the activity of ion channels and pumps …
Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes
RD Nicholls, JL Knepper - Annual review of genomics and …, 2001 - annualreviews.org
The chromosomal region, 15q11-q13, involved in Prader-Willi and Angelman syndromes
(PWS and AS) represents a paradigm for understanding the relationships between genome …
(PWS and AS) represents a paradigm for understanding the relationships between genome …
Analysis of GABAA Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics
U Rudolph, H Möhler - Annu. Rev. Pharmacol. Toxicol., 2004 - annualreviews.org
GABAA receptors are molecular substrates for the regulation of vigilance, anxiety, muscle
tension, epileptogenic activity, and memory functions, and the enhancement of GABAA …
tension, epileptogenic activity, and memory functions, and the enhancement of GABAA …
The diversity of GABAA receptors: Pharmacological and electrophysiological properties of GABAA channel subtypes
W Hevers, H Lüddens - Molecular neurobiology, 1998 - Springer
The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …
Drug interactions at GABAA receptors
ER Korpi, G Gründer, H Lüddens - Progress in neurobiology, 2002 - Elsevier
Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …
research for more than 20 years for basic and applied scientific reasons, but only recently …
Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
GE Homanics, TM DeLorey… - Proceedings of the …, 1997 - National Acad Sciences
γ-Aminobutyric acid type A receptors (GABAA-Rs) mediate the bulk of rapid inhibitory
synaptic transmission in the central nervous system. The β3 subunit is an essential …
synaptic transmission in the central nervous system. The β3 subunit is an essential …