Src and Src-family protein kinases are proto-oncogenes that play key roles in cell
morphology, motility, proliferation, and survival. v-Src (a viral protein) is encoded by the …

The non-receptor tyrosine kinase Csk serves as an indispensable negative regulator of the
Src family tyrosine kinases (SFKs) by specifically phosphorylating the negative regulatory …

The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase
families found in the human genome. Members of these kinase families function …

Highlights•Protein–protein interactions are essential for almost all cell processes.•Peptides
are ideal candidates for targeting protein–protein interactions (PPIs).•We survey screening …

To achieve high biological specificity, protein kinases and phosphatases often recognize
their targets through interactions that occur outside of the active site. Although the role of …

Abstract Background Mitogen Activated Protein Kinase (MAPK) signaling is of critical
importance in plants and other eukaryotic organisms. The MAPK cascade plays an …

Tyrosine kinases were first discovered as the protein products of viral oncogenes. We now
know that this large family of metazoan enzymes includes nearly one hundred structurally …

Bidirectional signaling triggered by interacting ephrinB receptors (EphB) and ephrinB
ligands is crucial for development and function of the vascular and nervous systems. A …

Despite the efforts of pharmaceutical companies to develop specific kinase modulators, few
drugs targeting kinases have been completely successful in the clinic. This is primarily due …

Accumulating evidence suggests that protein tyrosine phosphorylation-based signaling
pathways are under the regulation of reactive oxygen species. Although protein tyrosine …