Dopamine receptors–IUPHAR R eview 13
The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders
Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …
bipolar disorder and major depression. More recently, based on findings from translational …
Inhibition of GSK3 by lithium, from single molecules to signaling networks
L Freland, JM Beaulieu - Frontiers in molecular neuroscience, 2012 - frontiersin.org
For more than 60 years, the mood stabilizer lithium has been used alone or in combination
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …
A model of the mitochondrial basis of bipolar disorder
G Morris, K Walder, SL McGee, OM Dean… - Neuroscience & …, 2017 - Elsevier
Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …
availability; increased in mania and decreased in depression. In consort, there is …
GSK-3 and Wnt signaling in neurogenesis and bipolar disorder
AJ Valvezan, PS Klein - Frontiers in molecular neuroscience, 2012 - frontiersin.org
The canonical Wnt signaling pathway is critical for development of the mammalian central
nervous system and regulates diverse processes throughout adulthood, including adult …
nervous system and regulates diverse processes throughout adulthood, including adult …
Advances toward precision medicine for bipolar disorder: mechanisms & molecules
Given its chronicity, contribution to disability and morbidity, and prevalence of more than 2%,
the effective treatment, and prevention of bipolar disorder represents an area of significant …
the effective treatment, and prevention of bipolar disorder represents an area of significant …
Insulin signaling as a therapeutic mechanism of lithium in bipolar disorder
IH Campbell, H Campbell, DJ Smith - Translational Psychiatry, 2022 - nature.com
In this paper, we propose that lithium may exert its therapeutic effect in bipolar disorder by
acting on insulin signaling pathways. Specifically, we assess the importance of the …
acting on insulin signaling pathways. Specifically, we assess the importance of the …
Glycogen synthase kinase-3 in the etiology and treatment of mood disorders
RS Jope - Frontiers in molecular neuroscience, 2011 - frontiersin.org
The mood disorders major depressive disorder and bipolar disorder are prevalent, are
inadequately treated, and little is known about their etiologies. A better understanding of the …
inadequately treated, and little is known about their etiologies. A better understanding of the …
Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors
JM Beaulieu, T Del'Guidice, TD Sotnikova… - Frontiers in molecular …, 2011 - frontiersin.org
Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent …
compounds developed for the treatment of various neuropsychiatric disorders. Recent …
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are
projected to lead global disease burden within the next decade. Pharmacotherapy, the …
projected to lead global disease burden within the next decade. Pharmacotherapy, the …