Acute respiratory distress syndrome

MA Matthay, RL Zemans, GA Zimmerman… - Nature reviews Disease …, 2019 - nature.com
The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Acute respiratory distress syndrome heterogeneity and the septic ARDS subgroup

H Xu, S Sheng, W Luo, X Xu, Z Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is an acute diffuse inflammatory lung injury
characterized by the damage of alveolar epithelial cells and pulmonary capillary endothelial …

Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation

O Gajic, SI Dara, JL Mendez, AO Adesanya… - Critical care …, 2004 - journals.lww.com
Objective: Although ventilation with small tidal volumes is recommended in patients with
established acute lung injury, most others receive highly variable tidal volume aimed in part …

Salmeterol for the prevention of high-altitude pulmonary edema

C Sartori, Y Allemann, H Duplain… - … England Journal of …, 2002 - Mass Medical Soc
Background Pulmonary edema results from a persistent imbalance between forces that drive
water into the air space and the physiologic mechanisms that remove it. Among the latter …

[HTML][HTML] Acute renal failure leads to dysregulation of lung salt and water channels

H Rabb, Z Wang, T Nemoto, J Hotchkiss, N Yokota… - Kidney international, 2003 - Elsevier
Acute renal failure leads to dysregulation of lung salt and water channels. Background
Renal ischemia/reperfusion (I/R) injury and the acute respiratory distress syndrome (ARDS) …

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection

C Peteranderl, L Morales-Nebreda, B Selvakumar… - The Journal of clinical …, 2016 - jci.org
Influenza A viruses (IAV) can cause lung injury and acute respiratory distress syndrome
(ARDS), which is characterized by accumulation of excessive fluid (edema) in the alveolar …

Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome

M Cepkova, MA Matthay - Journal of intensive care …, 2006 - journals.sagepub.com
Acute lung injury and the acute respiratory distress syndrome are common syndromes with a
high mortality rate that affect both medical and surgical patients. Better understanding of the …

The contribution of epithelial sodium channels to alveolar function in health and disease

DC Eaton, MYN Helms, M Koval… - Annual review of …, 2009 - annualreviews.org
Amiloride-sensitive epithelial sodium channels (ENaC) play an important role in lung
sodium transport. Sodium transport is closely regulated to maintain an appropriate fluid layer …

Science review: mechanisms of ventilator-induced injury

JA Frank, MA Matthay - Critical Care, 2002 - Springer
Acute respiratory distress syndrome (ARDS) and acute lung injury are among the most
frequent reasons for intensive care unit admission, accounting for approximately one-third of …

AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis

I Vadász, LA Dada, A Briva, HE Trejo, LC Welch… - The Journal of clinical …, 2008 - jci.org
Hypercapnia (elevated CO2 levels) occurs as a consequence of poor alveolar ventilation
and impairs alveolar fluid reabsorption (AFR) by promoting Na, K-ATPase endocytosis. We …