The use of vaccination against the influenza virus remains the most effective method of
mitigating the significant morbidity and mortality caused by this virus. Antibodies elicited by …

B18R protein of Vaccinia virus binds to type I interferons and inhibits activation of interferon-
mediated signal transduction. Cells which have unimpaired interferon signaling such as …

Abstract β‐thalassemia is a common autosomal recessive disorder characterized by a
deficiency in the synthesis of β‐chains. Evidences show that increased HbF levels improve …

HIV-1 based lentiviruses are commonly used to integrate foreign genetic material into target
cells. Typically, this involves the mass transfection of packaging cells with the packaging …

Background Targeting of specific tissues and cells by viruses is one of the challenges faced
by researchers. Lentiviral vectors (LVs) are one of the most promising gene delivery systems …

Today, lentiviral vectors are favorable vectors for RNA interference delivery in anti-HIV
therapeutic approaches. Nevertheless, problems such as the specific recognition of target …

Gene targeting by homologous recombination (HR) has some disadvantages in screening
modified cells that limits their use in targeting gene fragments in long exons. These …

A major challenge of cell-based therapies is the appropriate and effective localization of
cells to target sites. Engineering cell migration to a specific target site can offer a promising …

Malignant hyperthermia (MH) is an uncommon pharmacogenetic disorder that is
asymptomatic until triggered by volatile anaesthetics or depolarising muscle relaxants …

The model alphavirus Venezuelan equine encephalitis virus (VEE) exhibits non-cytopathic
replication in cell cultures. In this study, the ability of VEE to infect cells of different types was …