New insights into the role of TREM2 in Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …
Treatment of Alzheimer's disease and blood–brain barrier drug delivery
WM Pardridge - Pharmaceuticals, 2020 - mdpi.com
Despite the enormity of the societal and health burdens caused by Alzheimer's disease
(AD), there have been no FDA approvals for new therapeutics for AD since 2003. This …
(AD), there have been no FDA approvals for new therapeutics for AD since 2003. This …
A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies
The neurotransmitter acetylcholine (ACh) regulates a diverse array of physiological
processes throughout the body. Despite its importance, cholinergic transmission in the …
processes throughout the body. Despite its importance, cholinergic transmission in the …
Multi-target design strategies for the improved treatment of Alzheimer's disease
P Zhang, S Xu, Z Zhu, J Xu - European journal of medicinal chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a multifactorial syndrome resulting in profound misery and
poses a substantial burden on human health, economy, and society throughout the world …
poses a substantial burden on human health, economy, and society throughout the world …
Meta-analysis of randomized controlled trials on the efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's …
DD Li, YH Zhang, W Zhang, P Zhao - Frontiers in neuroscience, 2019 - frontiersin.org
To study the impact of donepezil, rivastigmine, galantamine, and memantine on cognitive,
functional, behavioral, global changes and adverse effects in patients with mild, moderate …
functional, behavioral, global changes and adverse effects in patients with mild, moderate …
[HTML][HTML] Recent advances in the neurobiology and neuropharmacology of Alzheimer's disease
K Kumar, A Kumar, RM Keegan… - Biomedicine & …, 2018 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …
progressive deterioration of cognitive functions. The pathological hallmarks are extracellular …
Benzimidazole-based schiff base hybrid scaffolds: a promising approach to develop multi-target drugs for alzheimer's disease
A series of benzimidazole-based Schiff base derivatives (1–18) were synthesized and
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
structurally elucidated through 1H NMR, 13C NMR and HREI-MS analysis. Subsequently …
Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease
J Prickaerts, PRA Heckman… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: Phosphodiesterase (PDE) inhibitors improve signaling pathways in brain
circuits by increasing intracellular cyclic adenosine monophosphate (cAMP) and/or cyclic …
circuits by increasing intracellular cyclic adenosine monophosphate (cAMP) and/or cyclic …
Alzheimer's disease and language impairments: social intervention and medical treatment
B Klimova, P Maresova, M Valis, J Hort… - Clinical interventions in …, 2015 - Taylor & Francis
Communication is very important for people to be successfully integrated into social
environment and make and maintain relationship. Particularly, language difficulties lead to …
environment and make and maintain relationship. Particularly, language difficulties lead to …
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …