The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a
critical player in gut homeostasis maintenance as it ensures the complex crosstalk between …

The respiratory system, which consists of the lungs, trachea and associated vasculature, is
essential for terrestrial life. In recent years, extensive progress has been made in defining …

The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

Embryonic stem (ES) cells can be derived and propagated from multiple strains of mouse
and rat through application of small-molecule inhibitors of the fibroblast growth factor …

Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

Maintaining the integrity of the gastrointestinal tract, despite the continual presence of
microbial flora and injurious agents, is essential. Epithelial continuity depends on a family of …

Abstract dHAND and eHAND are related basic helix-loop-helix (bHLH) transcription factors
that are expressed in mesodermal and neural crest-derived structures of the develo** …

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the
three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo …