Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

ZA Sherif, CR Gomez, TJ Connors, TJ Henrich… - Elife, 2023 - elifesciences.org
COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional
malaise, and cognitive dysfunction that last for months and impact everyday functioning, is …

[HTML][HTML] Long-term respiratory and neurological sequelae of COVID-19

F Wang, RM Kream, GB Stefano - Medical science monitor …, 2020 - ncbi.nlm.nih.gov
Since the initial reports of coronavirus disease 2019 (COVID-19) in China in late 2019,
infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have …

[HTML][HTML] Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

RA Flynn, JA Belk, Y Qi, Y Yasumoto, J Wei… - Cell, 2021 - cell.com
SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using
comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) …

SARS‐CoV‐2 and mitochondrial proteins in neural‐derived exosomes of COVID‐19

MJ Peluso, SG Deeks, M Mustapic… - Annals of …, 2022 - Wiley Online Library
Objective As SARS‐CoV‐2 is known to invade neural cell mitochondria, a plasma system for
quantifying central nervous system proteins in living humans was used to investigate …

SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment

C Shang, Z Liu, Y Zhu, J Lu, C Ge, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Mitochondria, which is essential for adequate innate immune response, energy metabolism
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …

[HTML][HTML] Role of machine learning techniques to tackle the COVID-19 crisis: systematic review

HB Syeda, M Syed, KW Sexton, S Syed… - JMIR medical …, 2021 - medinform.jmir.org
Background: SARS-CoV-2, the novel coronavirus responsible for COVID-19, has caused
havoc worldwide, with patients presenting a spectrum of complications that have pushed …

[HTML][HTML] Selective neuronal mitochondrial targeting in SARS-CoV-2 infection affects cognitive processes to induce 'brain fog'and results in behavioral changes that …

GB Stefano, R Ptacek, H Ptackova… - … medical journal of …, 2021 - ncbi.nlm.nih.gov
Alterations in brain functioning, especially in regions associated with cognition, can result
from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and are …

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

TJ Costa, SR Potje, TFC Fraga-Silva… - Vascular …, 2022 - Elsevier
Background and purpose Mitochondria play a central role in the host response to viral
infection and immunity, being key to antiviral signaling and exacerbating inflammatory …

SARS-CoV-2 mediated endothelial dysfunction: the potential role of chronic oxidative stress

R Chang, A Mamun, A Dominic, NT Le - Frontiers in physiology, 2021 - frontiersin.org
Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19
inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation …

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …