Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Alzheimer's disease (AD) is characterized by an imbalance between production and
clearance of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

The amyloid fibrils of beta-amyloid (Aβ) peptides play important roles in the pathology of
Alzheimer's disease. Comprehensive solid-state NMR (SSNMR) structural studies on …

The presence of amyloid plaques composed of amyloid beta (Aβ) fibrils is a hallmark of
Alzheimer's disease (AD). The Aβ peptide is present as several length variants with two …

Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer's disease (AD), but the
early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical …

Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is
challenging owing to the vast heterogeneity of the resulting soluble aggregates. To …

Amyloidopathic disorders such as Alzheimer's disease present symptomology years after
the entrenchment of amyloidogenic imbalance. The pathologic α-helix→ β-strand …

The amyloid β (Aβ) peptides are 39–42 residue-long peptides found in the senile plaques in
the brains of Alzheimer's disease (AD) patients. These peptides self-aggregate in aqueous …

Pathological protein and peptide aggregation are key events in a number of chronic and
devastating neurodegenerative conditions including dementias such as Alzheimer's and …