Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

There has been exponential growth in the number of membrane protein structures
determined. Nevertheless, these structures are usually resolved in the absence of their lipid …

Detergents are widely used for membrane protein solubilization, purification, and structural
analysis. Over the past two decades, much effort has been made to design novel detergents …

Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global
healthcare burden,. In clinical strains, resistance is largely controlled by BlaR1, a receptor …

The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human
health and disease. The importance of this pathway is underscored by the discovery that two …

Polar lipids and membrane proteins are major components of biological membranes, both
cell membranes and membranes of enveloped viruses. How these two classes of membrane …

The cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These
ubiquitous enzymes participate in all major physiological processes, and so their …

Since the identification of the first disease causing mutation in the gene coding for emerin, a
transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants …

CAAX proteins have essential roles in multiple signalling pathways, controlling processes
such as proliferation, differentiation and carcinogenesis. The∼ 120 mammalian CAAX …