Sex-and gender-based pharmacological response to drugs
In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …
of biologic sex produces different in vivo environments for male and female cells. We dissect …
Gender differences in the effects of cardiovascular drugs
An initiation-promotion protocol was used to test the hypothesis that unleaded gasoline (UG)
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …
vapor acts as a liver tumor promoter in female mice under exposure conditions in which UG …
Safety and efficacy of fluvoxamine in COVID‐19 ICU patients: an open label, prospective cohort trial with matched controls
M Calusic, R Marcec, L Luksa, I Jurkovic… - British journal of …, 2022 - Wiley Online Library
Aims Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma‐1 receptor
agonist, has so far shown promise in the prevention of COVID‐19 progression as an early …
agonist, has so far shown promise in the prevention of COVID‐19 progression as an early …
PharmVar GeneFocus: CYP2C19
The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele
nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation …
nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation …
Clinical significance of the cytochrome P450 2C19 genetic polymorphism
Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …
How important are gender differences in pharmacokinetics?
Gender-related differences in pharmacokinetics have frequently been considered as
potentially important determinants for the clinical effectiveness of drug therapy. The …
potentially important determinants for the clinical effectiveness of drug therapy. The …
Antipsychotic medication for women with schizophrenia spectrum disorders
There are significant differences between men and women in the efficacy and tolerability of
antipsychotic drugs. Here, we provide a comprehensive overview of what is currently known …
antipsychotic drugs. Here, we provide a comprehensive overview of what is currently known …
Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics
GD Anderson - Journal of women's health, 2005 - liebertpub.com
The Food and Drug Administration (FDA) reviewed 300 new drug applications between
1995 and 2000. Of the 163 that included a sex analysis, 11 drugs showed a> 40% difference …
1995 and 2000. Of the 163 that included a sex analysis, 11 drugs showed a> 40% difference …
Women encounter ADRs more often than do men
Y Zopf, C Rabe, A Neubert, KG Gassmann… - European journal of …, 2008 - Springer
Background Several publications indicate that the female gender experiences a higher
incidence of adverse drug reactions (ADRs) than does the male gender. The reasons …
incidence of adverse drug reactions (ADRs) than does the male gender. The reasons …
Impact of the Ultrarapid CYP2C19*17 Allele on Serum Concentration of Escitalopram in Psychiatric Patients
I Rudberg, B Mohebi, M Hermann… - Clinical …, 2008 - Wiley Online Library
Recently, a novel allelic variant of cytochrome P450 2C19 encoding ultrarapid enzyme
activity was described (denoted CYP2C19* 17). The objective of this study was to evaluate …
activity was described (denoted CYP2C19* 17). The objective of this study was to evaluate …