Hebb postulated that, to store information in the brain, assemblies of excitatory neurons
coding for a percept are bound together via associative long-term synaptic plasticity. In this …

Understanding how brains process information is an incredibly difficult task. Amongst the
metrics characterising information processing in the brain, observations of dynamic near …

The functional interplay between the corticolimbic GABAergic and opioidergic systems plays
a crucial role in regulating the reward system and cognitive aspects of motivational …

Adaptivity is a dynamical feature that is omnipresent in nature, socio-economics, and
technology. For example, adaptive couplings appear in various real-world systems, such as …

Understanding how biological neural networks carry out learning using spike-based local
plasticity mechanisms can lead to the development of real-time, energy-efficient, and …

Sensory experiences and learning induce long-lasting changes in both excitatory and
inhibitory synapses, thereby providing a crucial substrate for memory. However, the co …

Develo** neural circuits show unique patterns of spontaneous activity and structured
network connectivity shaped by diverse activity-dependent plasticity mechanisms. Based on …

A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative
development of cortex-wide E/I ratio remains unknown. Here, we noninvasively estimate a …

The nuclear receptors of thyroid hormone exert a broad influence on brain development and
then on adult brain physiology. However, the cell-autonomous function of the receptors is …

The molecular mechanisms underlying the neurodevelopmental disorders (NDDs) caused
by DDX3X variants remain poorly understood. In this study, we validated that de novo …