Patients with a diverse spectrum of rare genetic disorders can present with inflammatory
bowel disease (monogenic IBD). Patients with these disorders often develop symptoms …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating
immune responses during host defense but also in autoimmune disorders, inflammatory …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

Very early onset inflammatory bowel disease (VEO-IBD) is a unique disease entity with a
complex genetic susceptibility in affected patients. Next-generation gene sequencing …

The rate of pediatric inflammatory bowel disease (IBD) has been increasing over the last
decade and this increase has occurred most rapidly in the youngest children diagnosed< 6 …

Background & Aims Very early onset inflammatory bowel disease (VEO-IBD), IBD diagnosed
at 5 years of age or younger, frequently presents with a different and more severe phenotype …

Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is
characterized by chronic intestinal inflammation due to a complex interaction of genetic …

In a recent issue of the Lancet, the prevalence of Inflammatory Bowel Disease (IBD) was
estimated at 7 million worldwide. Overall, the burden of IBD is rising globally, with direct and …

Background Insight into the pathogenesis of very early onset-inflammatory bowel disease
(VEO-IBD) has expanded through the identification of causative monogenic defects detected …

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-
onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular …