RD Mullins, JA Heuser… - Proceedings of the …, 1998 - National Acad Sciences
The Arp2/3 complex is a stable assembly of seven protein subunits including two actin-
related proteins (Arp2 and Arp3) and five novel proteins. Previous work showed that this …
related proteins (Arp2 and Arp3) and five novel proteins. Previous work showed that this …
Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
▪ Abstract We review how motile cells regulate actin filament assembly at their leading edge.
Activation of cell surface receptors generates signals (including activated Rho family …
Activation of cell surface receptors generates signals (including activated Rho family …
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
TM Svitkina, GG Borisy - The Journal of cell biology, 1999 - rupress.org
The leading edge (∼ 1 μm) of lamellipodia in Xenopus laevis keratocytes and fibroblasts
was shown to have an extensively branched organization of actin filaments, which we term …
was shown to have an extensively branched organization of actin filaments, which we term …
A barbed end interference mechanism reveals how cap** protein promotes nucleation in branched actin networks
Heterodimeric cap** protein (CP/CapZ) is an essential factor for the assembly of branched
actin networks, which push against cellular membranes to drive a large variety of cellular …
actin networks, which push against cellular membranes to drive a large variety of cellular …
Cap** protein regulators fine-tune actin assembly dynamics
Cap** protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …
Regulation of actin assembly associated with protrusion and adhesion in cell migration
C Le Clainche, MF Carlier - Physiological reviews, 2008 - journals.physiology.org
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …
Mechanism and function of formins in the control of actin assembly
Formins are a widely expressed family of proteins that govern cell shape, adhesion,
cytokinesis, and morphogenesis by remodeling the actin and microtubule cytoskeletons …
cytokinesis, and morphogenesis by remodeling the actin and microtubule cytoskeletons …
Force feedback controls motor activity and mechanical properties of self-assembling branched actin networks
Branched actin networks—created by the Arp2/3 complex, cap** protein, and a nucleation
promoting factor—generate and transmit forces required for many cellular processes, but …
promoting factor—generate and transmit forces required for many cellular processes, but …