ICU-acquired weakness
I Vanhorebeek, N Latronico, G Van den Berghe - Intensive care medicine, 2020 - Springer
Critically ill patients often acquire neuropathy and/or myopathy labeled ICU-acquired
weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk …
weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk …
The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis
Background Patients with critical illness can lose more than 15% of muscle mass in one
week, and this can have long-term detrimental effects. However, there is currently no …
week, and this can have long-term detrimental effects. However, there is currently no …
Long-term cognitive impairment and functional disability among survivors of severe sepsis
Context Cognitive impairment and functional disability are major determinants of caregiving
needs and societal health care costs. Although the incidence of severe sepsis is high and …
needs and societal health care costs. Although the incidence of severe sepsis is high and …
Clinical review: intensive care unit acquired weakness
G Hermans, G Van den Berghe - Critical care, 2015 - Springer
A substantial number of patients admitted to the ICU because of an acute illness,
complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle …
complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
Acute outcomes and 1-year mortality of intensive care unit–acquired weakness. A cohort study and propensity-matched analysis
G Hermans, H Van Mechelen, B Clerckx… - American journal of …, 2014 - atsjournals.org
Rationale: Intensive care unit (ICU)-acquired weakness is a frequent complication of critical
illness. It is unclear whether it is a marker or mediator of poor outcomes. Objectives: To …
illness. It is unclear whether it is a marker or mediator of poor outcomes. Objectives: To …
Sepsis induces interleukin 6, gp130/JAK2/STAT3, and muscle wasting
L Zanders, M Kny, A Hahn, S Schmidt… - Journal of cachexia …, 2022 - Wiley Online Library
Background Sepsis and inflammation can cause intensive care unit‐acquired weakness
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …
An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit–acquired weakness in adults
Rationale: Profound muscle weakness during and after critical illness is termed intensive
care unit–acquired weakness (ICUAW). Objectives: To develop diagnostic …
care unit–acquired weakness (ICUAW). Objectives: To develop diagnostic …
ICU-acquired weakness
Survivorship after critical illness is an increasingly important health-care concern as ICU use
continues to increase while ICU mortality is decreasing. Survivors of critical illness …
continues to increase while ICU mortality is decreasing. Survivors of critical illness …
The decision to extubate in the intensive care unit
AW Thille, JCM Richard, L Brochard - American journal of …, 2013 - atsjournals.org
The day of extubation is a critical time during an intensive care unit (ICU) stay. Extubation is
usually decided after a weaning readiness test involving spontaneous breathing on a T …
usually decided after a weaning readiness test involving spontaneous breathing on a T …