Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS) …

Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-
faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

During aging, deterioration in cardiac structure and function leads to increased susceptibility
to heart failure. The need for interventions to combat this age-related cardiac decline is …