Epigenetic pathways are essential in different biological processes and in phenotype-
environment interactions in response to different stressors and they can induce phenotypic …

ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

A multitude of histone chaperones are required to support histones from their biosynthesis
until DNA deposition. They cooperate through the formation of histone co-chaperone …

Nucleosomes represent the fundamental repeating unit of eukaryotic DNA, and comprise
eight core histones around which DNA is wrapped in nearly two superhelical turns. Histones …

Simple Summary The gene encoding for the epigenetic regulator ATRX is gaining a
prominent position among the most important oncosuppressive genes of the human …

In most species, the centromere is comprised of repetitive DNA sequences, which rapidly
evolve. Paradoxically, centromeres fulfill an essential function during mitosis, as they are the …

Heterochromatin is a critical chromatin compartment, whose integrity governs genome
stability and cell fate transitions. How heterochromatin features, including higher-order …

The relatively quiet mutational landscape of rhabdomyosarcoma (RMS) suggests that
epigenetic deregulation could be central to oncogenesis and tumour aggressiveness …

The central dogma of molecular genetics is defined as encoded genetic information within
DNA, transcribed into messenger RNA, which contain the instructions for protein synthesis …

Skeletal muscles consist of fibers of differing metabolic activities and contractility, which
become remodeled in response to chronic exercise, but the epigenomic basis for muscle …