The use of viral vectors in vaccine development
Vaccines represent the single most cost-efficient and equitable way to combat and eradicate
infectious diseases. While traditional licensed vaccines consist of either …
infectious diseases. While traditional licensed vaccines consist of either …
Fatty acid transport protein 2 reprograms neutrophils in cancer
Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically
activated neutrophils that are crucial for the regulation of immune responses in cancer …
activated neutrophils that are crucial for the regulation of immune responses in cancer …
Lentiviral vectors as a vaccine platform against infectious diseases
K Nemirov, M Bourgine, F Anna, Y Wei, P Charneau… - Pharmaceutics, 2023 - mdpi.com
Lentiviral vectors are among the most effective viral vectors for vaccination. In clear contrast
to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing …
to the reference adenoviral vectors, lentiviral vectors have a high potential for transducing …
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
Cross-presentation is a critical function of dendritic cells (DCs) required for induction of
antitumor immune responses and success of cancer immunotherapy. It is established that …
antitumor immune responses and success of cancer immunotherapy. It is established that …
Use of lentiviral vectors in vaccination
MW Ku, P Charneau, L Majlessi - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction Lentiviral vectors have emerged as powerful vectors for vaccination, due to their
high efficiency to transduce dendritic cells and to induce long-lasting humoral immunity …
high efficiency to transduce dendritic cells and to induce long-lasting humoral immunity …
An update on the HIV DNA vaccine strategy
In 2020, the global prevalence of human immunodeficiency virus (HIV) infection was
estimated to be 38 million, and a total of 690,000 people died from acquired …
estimated to be 38 million, and a total of 690,000 people died from acquired …
Integrase-defective lentiviral vector is an efficient vaccine platform for cancer immunotherapy
V Morante, M Borghi, I Farina, Z Michelini, F Grasso… - Viruses, 2021 - mdpi.com
Integrase-defective lentiviral vectors (IDLVs) have been used as a safe and efficient delivery
system in several immunization protocols in murine and non-human primate preclinical …
system in several immunization protocols in murine and non-human primate preclinical …
Strategies for inducing effective neutralizing antibody responses against HIV-1
Introduction: Despite intensive research efforts, there is still no effective prophylactic vaccine
available against HIV-1. Currently, substantial efforts are devoted to the development of …
available against HIV-1. Currently, substantial efforts are devoted to the development of …
Integrase defective lentiviral vector as a vaccine platform for delivering influenza antigens
A Gallinaro, M Borghi, R Bona, F Grasso… - Frontiers in …, 2018 - frontiersin.org
Viral vectors represent an attractive technology for vaccine delivery. We exploited the
integrase defective lentiviral vector (IDLV) as a platform for delivering relevant antigens …
integrase defective lentiviral vector (IDLV) as a platform for delivering relevant antigens …
Establishment, persistence, and reactivation of latent HIV-1 infection in renal epithelial cells
EJ Baker, K Hughes, T Travieso, ME Klotman… - Journal of …, 2022 - Am Soc Microbiol
ABSTRACT HIV-1 persistence in different cell types presents the main obstacle to an HIV-1
cure. We have previously shown that the renal epithelium is a site of HIV-1 infection and that …
cure. We have previously shown that the renal epithelium is a site of HIV-1 infection and that …