Quinoline hybrids and their antiplasmodial and antimalarial activities

YQ Hu, C Gao, S Zhang, L Xu, Z Xu, LS Feng… - European Journal of …, 2017‏ - Elsevier
Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

Quinolines and structurally related heterocycles as antimalarials

K Kaur, M Jain, RP Reddy, R Jain - European journal of medicinal …, 2010‏ - Elsevier
The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

Primaquine revisited six decades after its discovery

N Vale, R Moreira, P Gomes - European journal of medicinal chemistry, 2009‏ - Elsevier
Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …

Recent developments in the design and synthesis of hybrid molecules basedon aminoquinoline ring and their antiplasmodial evaluation

VV Kouznetsov, A Gómez-Barrio - European journal of medicinal chemistry, 2009‏ - Elsevier
A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …

Recent advances in antimalarial drug development

S Vangapandu, M Jain, K Kaur, P Patil… - Medicinal research …, 2007‏ - Wiley Online Library
Malaria caused by protozoa of the genus Plasmodium, because of its prevalence, virulence,
and drug resistance, is the most serious and widespread parasitic disease encountered by …

Ring-substituted quinolines as potential anti-tuberculosis agents

S Vangapandu, M Jain, R Jain, S Kaur… - Bioorganic & medicinal …, 2004‏ - Elsevier
We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1–4)
constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv …

Theoretical insights into the anti-SARS-CoV-2 activity of chloroquine and its analogs and in silico screening of main protease inhibitors

AS Achutha, VL Pushpa, S Suchitra - Journal of proteome …, 2020‏ - ACS Publications
Corona virus disease (COVID-19) is a dangerous disease rapidly spreading all over the
world today. Currently there are no treatment options for it. Drug repurposing studies …

Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues

M Jain, SI Khan, BL Tekwani, MR Jacob… - Bioorganic & medicinal …, 2005‏ - Elsevier
In the present communication, newly synthesized 8-quinolinamines (25–27) related to
previously reported 2-tert-butylprimaquine (2) were evaluated for their in vitro antimalarial …

Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis (8-aminoquinolines)

K Kaur, M Jain, SI Khan, MR Jacob, BL Tekwani… - Bioorganic & medicinal …, 2011‏ - Elsevier
In continuing our search of potent antimalarials based on 8-aminoquinoline structural
framework, three series of novel bis (8-aminoquinolines) using convenient one to four steps …

Urea and carbamate derivatives of primaquine: Synthesis, cytostatic and antioxidant activities

M Šimunović, I Perković, B Zorc, K Ester, M Kralj… - Bioorganic & medicinal …, 2009‏ - Elsevier
The novel urea primaquine derivatives 3 were prepared by aminolysis of primaquine
benzotriazolide 2 with several hydroxyamines and ethylendiamine, while carbamates 4 …