Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Alzheimer's disease (AD) is associated with deficiencies in cerebrovascular functions, eg
reduced cerebral blood flow and capillary amyloid angiopathy, both of which are evident …

Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and
amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain …

A variety of environmental stresses like chemicals, UV and ionizing radiation and organism's
endogenous processes such as replication stress and metabolism can lead to the …

Rodent models have been extensively used to investigate the cause and mechanisms
behind Alzheimer's disease. Despite many years of intensive research using these models …

Over the past century, advances in biotechnology, biochemistry, and pharmacognosy have
spotlighted flavonoids, polyphenolic secondary metabolites that have the ability to modulate …

Alzheimer's disease (AD) has become increasingly prevalent in the elderly population
across the world. It's pathophysiological markers such as overproduction along with the …

Metformin (MET) is among the most consumed drugs around the world, and thus, it is
considered the uppermost drug in mass discharged into water settings. Nonetheless, data …

High levels of reactive oxygen species (ROS) may cause a change of cellular redox state
towards oxidative stress condition. This situation causes oxidation of molecules (lipid, DNA …