Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Our understanding of the molecular properties of kainate receptors and their involvement in
synaptic physiology has progressed significantly over the last 30 years. A plethora of studies …

Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …

Long-term potentiation (LTP) of synaptic transmission is thought to be an important cellular
mechanism underlying memory formation. A widely accepted model posits that LTP requires …

Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open
their pores in response to binding of the agonist glutamate,–. An ionic current through a …

Two decades have passed since the first report of the cloning of a kainate-type glutamate
receptor (KAR) subunit. The intervening years have seen a rapid growth in our …

Kainate receptors, a subclass of ionotropic glutamate receptors, are tetrameric ligand-gated
ion channels that mediate excitatory neurotransmission,,–. Kainate receptors modulate …

Ionotropic neurotransmitter receptors mediate fast synaptic transmission by functioning as
ligand-gated ion channels. Fast inhibitory transmission in the brain is mediated mostly by …

Highlights•Complexes, supercomplexes and nanodomains are building blocks of the
synapse.•A tripartite mechanism dictates NMDA receptor complex assembly into …