Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …

Background & Aims Peroxisome proliferator-activated receptors (PPARs) have been
implicated in non-alcoholic steatohepatitis (NASH) pathogenesis, mainly based on animal …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver damage ranging from
simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. To date, no …

Abstract The pathophysiology of Non-Alcoholic Steatohepatitis (NASH) encompasses a
complex set of intra-and extrahepatic driving mechanisms, involving numerous metabolic …

Peroxisome proliferator-activated receptors (PPARs) are members of a family of nuclear
hormone receptors that exert their transcriptional control on genes harboring PPAR …

Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increasing prevalence
due to the obesity epidemic. Hence, NAFLD represents a rising threat to public health …

Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) comprises a wide spectrum of liver
injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis …

The liver X receptors (LXRs) are nuclear receptors that form permissive heterodimers with
retinoid X receptor (RXR) and are important regulators of lipid metabolism in the liver. We …