Oxygen Activation and Energy Conservation by Cytochrome c Oxidase
This review focuses on the type A cytochrome c oxidases (C c O), which are found in all
mitochondria and also in several aerobic bacteria. C c O catalyzes the respiratory reduction …
mitochondria and also in several aerobic bacteria. C c O catalyzes the respiratory reduction …
Copper active sites in biology
On the basis of its generally accessible I/II redox couple and bioavailability, copper plays a
wide variety of roles in nature that mostly involve electron transfer (ET), O 2 binding …
wide variety of roles in nature that mostly involve electron transfer (ET), O 2 binding …
Structural insights into functional properties of the oxidized form of cytochrome c oxidase
Cytochrome c oxidase (C c O) is an essential enzyme in mitochondrial and bacterial
respiration. It catalyzes the four-electron reduction of molecular oxygen to water and …
respiration. It catalyzes the four-electron reduction of molecular oxygen to water and …
Synthetic Fe/Cu complexes: toward understanding heme-copper oxidase structure and function
Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …
Long-range charge transfer mechanism of the III2IV2 mycobacterial supercomplex
D Riepl, AP Gamiz-Hernandez, T Kovalova… - Nature …, 2024 - nature.com
Aerobic life is powered by membrane-bound redox enzymes that shuttle electrons to oxygen
and transfer protons across a biological membrane. Structural studies suggest that these …
and transfer protons across a biological membrane. Structural studies suggest that these …
Adaptation of aerobic respiration to low O2 environments
Aerobic respiration in bacteria, Archaea, and mitochondria is performed by oxygen
reductase members of the heme-copper oxidoreductase superfamily. These enzymes are …
reductase members of the heme-copper oxidoreductase superfamily. These enzymes are …
Electric fields control water-gated proton transfer in cytochrome c oxidase
P Saura, D Riepl, DM Frey… - Proceedings of the …, 2022 - National Acad Sciences
Aerobic life is powered by membrane-bound enzymes that catalyze the transfer of electrons
to oxygen and protons across a biological membrane. Cytochrome c oxidase (C c O) …
to oxygen and protons across a biological membrane. Cytochrome c oxidase (C c O) …
Role of protonation states in the stability of molecular dynamics simulations of high-resolution membrane protein structures
Classical molecular dynamics (MD) simulations provide unmatched spatial and time
resolution of protein structure and function. However, the accuracy of MD simulations often …
resolution of protein structure and function. However, the accuracy of MD simulations often …
Characterizing the proton loading site in cytochrome c oxidase
J Lu, MR Gunner - Proceedings of the National Academy of …, 2014 - National Acad Sciences
Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive
eight charges from the high pH to low pH side of the membrane, increasing the …
eight charges from the high pH to low pH side of the membrane, increasing the …
Network analysis of a proposed exit pathway for protons to the P-side of cytochrome c oxidase
Abstract Cytochrome c Oxidase (CcO) reduces O 2, the terminal electron acceptor, to water
in the aerobic, respiratory electron transport chain. The energy released by O 2 reductions is …
in the aerobic, respiratory electron transport chain. The energy released by O 2 reductions is …